Angiotensin 1/2 (1-9)

Catalogue Number: A1007-APE

Manufacturer:	Apexbio
Molecular Weight:	1183.32
Molecular Formula:	C56H78N16O13
Physical state:	A solid
Type:	Peptide
Alias:	H2N-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-OH
Shipping Condition:	Blue Ice
Unit(s):	5 mg, 10 mg, 25 mg

Overview
Datasheets

Description

Description: Angiotensin I/II (1-9) is a peptide (ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-HIS) containing the amino acids 1-9 that are converted from Angiotensin I/II peptide.Angiotensin I is formed by the action of renin on angiotensinogen, which has 12 amino acids and is an α-2-globulin produced constitutively and released into the circulation mainly by the liver. Renin cleaves the peptide bond between the leucine (Leu) and valine (Val) residues on angiotensinogen, creating the ten-amino acid peptide angiotensin I. Angiotensin I is converted to angiotensin II (AII) through removal of two C-terminal residues by the enzymeangiotensin-converting enzyme (ACE), primarily through ACE within the lung.Angiotensin is a peptide hormone that causes vasoconstriction and a subsequent increase in blood pressure. Angiotensin also stimulates the release of aldosterone, which promotes sodium retention in the distal nephron so that drives blood pressure up. Figure1 Formula of Angiotensin I/II (1-9) Ref:1. Basso N, Terragno NA (December 2001). "History about the discovery of the renin-angiotensin system". Hypertension 38 (6): 1246-9. 2. Richard A. Preston. et. (1998). "Age-Race Subgroup Compared With Renin Profile as Predictors of Blood Pressure Response to Antihypertensive Therapy". JAMA. 1998;280(13):1168-1172.3. Williams GH, Dluhy RG (2008). "Chapter 336: Disorders of the Adrenal Cortex". In Loscalzo J, Fauci AS, Braunwald E, Kasper DL, Hauser SL, Longo DL. Harrison's principles of internal medicine. McGraw-Hill Medical.

Additional Text

Storage Note

Store at -20°C

Short Description

Vasoconstrictor

Reagent:Smile String

CCC(C)C(C(=O)NC(CC1=CN=CN1)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)NC(CC4=CN=CN4)C(=O)O)NC(=O)C(CC5=CC=C(C=C5)O)NC(=O)C(C(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC(=O)O)N