ALIX (Apoptosis-linked Gene 2 Interacting Protein X, ALG-2-interacting Protein 1, AIP1, Dopamine Receptor Interacting Protein 4, DRIP4, HP95, KIAA1375, MGC17003, Programmed Cell Death 6 Interacting Protein, PDCD6 Interacting Protein, PDCD6IP) (MaxLight 55

Catalogue Number: A1355-64A-ML550-USB

Manufacturer:	United States Biological
Physical state:	Supplied as a liquid in PBS, pH 7.2. Labeled with MaxLight™550.
Type:	Monoclonal Primary Antibody - Conjugated
Shipping Condition:	Blue Ice
Unit(s):	100 ul
Host name:	Mouse
Clone:	10B133 (3A9)
Isotype:	IgG1
Immunogen:	Alix-GST fusion protein.
Application:	IF, IP, WB, IHC, FLISA

Overview
Datasheets

Description

Description: MaxLight™550 is a new Yellow-Green photostable dye conjugate comparable to Alexa Fluor™546, 555, DyLight™549 , Cy3™, TRITC and offers better labeling efficiency, brighter imaging and increased immunodetection. Absorbance (550nm); Emission (575nm); Extinction Coefficient 150,000. Alix, a phylogenetically conserved cytosolic scaffold protein, contains an N-terminal Bro1 domain, a coiled-coil region and a C-terminal proline-rich domain. Originally identified as an ALG-2 (apoptosis-linked gene 2)-interacting protein involved in programmed cell death, Alix also regulates many other cellular processes, such as endocytic membrane trafficking and cell adhesion through interactions with ESCRT (endosomal sorting complex required for transport) proteins, endophilins, and CIN85 (Cbl-interacting protein of 85kD). Apoptosis-linked gene-2 interacting protein X (ALIX) is also known as Programmed cell death 6-interacting protein or Hp95. ALIX is a 868aa and a ~90kDa cytoplasmic protein containing a single BRO1 domain implicated in endosomal targeting. ALIX was first reported to play a role in apoptosis dependent on its association with PDCD6 but has subsequently shown to be involved in endocytosis, viral budding and actin cytoskeletal assembly. This product has been used extensively for the detection of ALIX by Western blot and for the identification of an ALIX homologue in the sea urchin Paracentrotus lividus.

Additional Text

Gene Name

PDCD6IP

Uniprot ID

Q8WUM4

Gene ID

10015

Specificity

Recognizes ALIX. Species Crossreactivity: human, Xenopus, rat and mouse.

Purification

Protein A purified

Antibody Clonality

Monoclonal

Full Name

ALIX (Apoptosis-linked Gene 2 Interacting Protein X, ALG-2-interacting Protein 1, AIP1, Dopamine Receptor Interacting Protein 4, DRIP4, HP95, KIAA1375, MGC17003, Programmed Cell Death 6 Interacting Protein, PDCD6 Interacting Protein, PDCD6IP) (MaxLight 550)

A1355-64A-ML550 Datasheet

Price

£832.00

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