Rabbit anti Human Caspase-9
Catalogue Number: A140P-EXA
| Manufacturer: | ExAlpha |
| Type: | Primary Antibody |
| Alias: | Cysteine-requiring Aspartate Protease-9; iCE-like apoptotic protease 6;Apoptotic protease Mch-6; Apoptotic protease-activating factor 3 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | Synthetic peptide corresponding to amino acids 301-313 of human caspase-9 |
| Application: | WB |
Description
Description: Caspase-9 exists as a pro-form (mw ~46 kDa) that is cleaved by the activity of Apaf-1 in the presence of cytosolic cytochrome c (Apaf-2) and dATP. The processing of pro-caspase-9 into a heterodimer consisting of a 35kDa and a 10 kDa chain activates the protease and induces the cascade leading to cleavage of caspase-3 and other apoptotic targets. The processing of caspase-9 may be blocked by the activity of bcl-x which physically interacts with the caspase-/Apaf-1 complex.
Additional Text
Gene Name
CASP9
Gene ID
842
Uniprot ID
P55211
Purification
Ammonium Sulfate Precipitated
Antibody Clonality
Polyclonal
Application Notes
Detects caspase-9 by Western blotting at 2-10 µg/ml. Optimal concentration should be evaluated by serial dilutions.
Storage Note
Product should be stored at -20C. Aliquot to avoid freeze/thaw cycles
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