Carfilzomib (PR-171)
Catalogue Number: A1933-APE
| Manufacturer: | Apexbio |
| Physical state: | A solid |
| Type: | Protease Inhibitors |
| Alias: | PR 171, PR171, PR-171, Carfilzomib |
| Shipping Condition: | Blue Ice |
| Unit(s): | 10 mg, 10 mM (in 1mL DMSO), 25 mg, 5 mg, SAMPLE |
Description
Description: An epoxomicin derivate with potential antineoplastic activity. It irreversibly binds to and inhibits the chymotrypsin-like activity of the 20S proteasome, an enzyme responsible for degrading a large variety of cellular proteins. Inhibition of proteasome-mediated proteolysis results in an accumulation of polyubiquinated proteins, which may lead to cell cycle arrest, induction of apoptosis, and inhibition of tumor growth.References: 1. Guido Cavaletti, et al., Leukemia & Lymphoma (2010), 51 (7), 1178-1187. 2. Girija Dasmahapatra, et al., Blood (2010), 115 (22), 4478-4487.
Additional Text
Reagent:Smile String
CC(C)CC(C(=O)C1(CO1)C)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(C)C)NC(=O)C(CCC3=CC=CC=C3)NC(=O)CN4CCOCC4
Short Description
Proteasome inhibitor, epoxomicin analog
Solubility
≥35.99 mg/mL in DMSO; insoluble in H2O; ≥2.64 mg/mL in EtOH with gentle warming and ultrasonic
Storage Note
Desiccate at -20°C
A1933 Datasheet
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