Sheep anti-Cytochrome C
Catalogue Number: A195P-NMB
| Manufacturer: | Nordic MuBio |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Shipping Condition: | RT |
| Unit(s): | 200 ul |
| Host name: | Sheep |
| Clone: | |
| Isotype: | |
| Immunogen: | Full length recombinant Cytochrome |
| Application: | IP, WB, IHC |
Description
Description: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases. Defects in CYCS are the cause of thrombocytopenia type 4 (THC4) also known as autosomal dominant thrombocytopenia type 4. Thrombocytopenia is the presence of relatively few platelets in blood. THC4 is a non-syndromic form of thrombocytopenia. Clinical manifestations of thrombocytopenia are absent or mild. THC4 may be caused by dysregulated platelet formation.
Additional Text
Gene Name
CYCS
Gene ID
475258
Uniprot ID
P00011
Antibody Clonality
Polyclonal
Application Notes
Western Blot|Immunoprecipitation|Immunohistochemistry
Storage Note
Product should be stored at -20C. Aliquot to avoid freeze/thaw cycles
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