Recombinant Human Apolipoprotein E2 (ApoE2)
Catalogue Number: A215-LET
| Manufacturer: | Leinco Technologies, Inc |
| Type: | Lipoprotein |
| Shipping Condition: | RT |
| Unit(s): | 500 ug |
| Application: | ELISA, WB, FA |
Description
Description: Apolipoprotein E (ApoE) produced by the liver and circulating macrophages, that is a constituent of every plasma lipoprotein except the smallest low density lipoproteins (LDL). It is a key player in the recycling and redistribution of lipids and cholesterol. ApoE is a ligand with a high affinity for low density lipoprotein receptors (LDLR). It regulates the activity of enzymes that metabolize lipids and also makes lipids soluble. Mice and humans that lack ApoE cannot remove excess lipoproteins from the plasma and have an increased risk of atherosclerosis. Defective binding of ApoE to its receptors will lead to accumulation of cholesterol-rich lipoprotein particles in the plasma; this is the cause of type III hyperlipoproteinemia. There are three main isoforms of ApoE all product of alleles at a single gene locus: E2 (Cys112, Cys158), E3 (C112, Arg158), and E4 (Arg112, Arg158). Inheritance of ApoE2 has been associated with lower levels of total cholesterol, low-density lipoprotein cholesterol and non-high-density lipoprotein cholesterol. E2 is associated with the genetic disorder type III hyperlipoproteinemia and with both increased and decreased risk for atherosclerosis.
Additional Text
Storage Note
The lyophilized protein should be stored desiccated at -20°C. The reconstituted protein can be stored for at least one week at 2-8°C. For long-term storage of the reconstituted protein, aliquot into working volumes and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
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