Amyloid Precursor Protein, Secretory (sAPP) (MaxLight 650)
Catalogue Number: A2275-71H-ML650-USB
| Manufacturer: | United States Biological |
| Physical state: | Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight™650. |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul |
| Host name: | Mouse |
| Clone: | 2Q18 (OM84) |
| Isotype: | IgG2a, kappa |
| Immunogen: | Amyloid Precursor Protein (APP) secreted by the EJ-1 bladder carcinoma cell line. |
| Application: | WB, FLISA |
Description
Description: MaxLight™650 is a new Far-IR stable dye conjugate comparable to Alexa Fluor™647, DyLight™649, Cy5™ and offers better labeling efficiency, brighter imaging and increased immunodetection. Absorbance (655nm); Emission (676nm); Extinction Coefficient 250,000. Amyloid Precursor Protein (APP) is an integral membrane protein with a large ectodomain, a transmembrane domain, and a short cytoplasmic tail. APP is proteolytically cleaved by b-secretase (BACE) to generate the APP N-terminal fragment (sbAPP) with Mr 100kD and a C-terminal fragment (C99) with Mr 12kD. The smaller 12kD fragment can be further cleaved by g-secretase, an enzyme activity recently attributed to presenilin-2. This second cleavage produces the insoluble b-amyloid (Ab), a peptide of ~4kD. The accumulation of b-amyloid in intracellular neurofibrillary tangles and extracellular plaques is observed in the brains of Alzheimer's disease patients and Downs's Syndrome patients.
Additional Text
Gene Name
APP
Gene ID
351
Uniprot ID
P05067
Specificity
Recognizes secretory amyloid precursor protein (sAPP). Does not recognize Amyloid-Beta protein 1-40.
Purification
Affinity Purified
Antibody Clonality
Monoclonal
A2275-71H-ML650 Datasheet
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