Ankyrin G (RFXANK, Regulatory Factor X) (APC)
Catalogue Number: A2295-18-APC-USB
| Manufacturer: | United States Biological |
| Physical state: | Supplied as a liquid in PBS, pH 7.2. No preservatives added. Labeled with Allophycocyanin (APC). |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul |
| Host name: | Mouse |
| Clone: | 3G8 |
| Isotype: | IgG1, kappa |
| Immunogen: | Synthetic peptide derived from the spectrin-binding domain of the human ankyrin G protein. |
| Application: | ELISA, IF, IP, WB |
Description
Description: Ankyrin G is found in several tissues including brain where, due to tissue-specific RNA processing, it is expressed as two different isoforms, localized to axon initial segments and nodes of Ranvier. Ankyrin G is also found at sites of epithelial cell- cell contact and in the intracellular membranes of some cells. Ankyrin G isoforms contain a unique stretch of sequence highly enriched in serine and threonine residues immediately following a globular head domain. Ankyrin G is thought to participate in the maintenance and targeting of ion channels and cell adhesion molecules to the nodes of Ranvier and to axon initial segments.
Additional Text
Specificity
Recognizes human Ankyrin G. Does not crossreact with related ankyrin isoforms. Also recognizes all splice forms of Ankyrin G containing a spectrin-binding domain Species Crossreactivity: mouse, rabbit, rat and canine.
Purification
Protein A purified
Antibody Clonality
Monoclonal
A2295-18-APC Datasheet
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