ASCL2 (Achaete-Scute Complex Homolog 2 (Drosophila), Achaete-scute Homolog 2, ASH2, ASH-2, bHLHa45, BHLHA45, Class A Basic Helix-loop-helix Protein 45, hASH2, HASH2, Mash2, MASH2) (FITC)

Catalogue Number: A3619-81-FITC-USB

Manufacturer:	United States Biological
Physical state:	Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with fluorescein isothiocyanate (FITC).
Type:	ChIP Validated Antibodies
Alias:	achaete-scute complex homolog 2\|achaete-scute complex-like 2\|achaete-scute homolog 2\|ASH2\|ASH-2\|bHLHa45\|class A basic helix-loop-helix protein 45\|HASH2\|mammalian achaete/scute homologue 2\|MASH2
Shipping Condition:	Blue Ice
Unit(s):	100 ul
Host name:	Mouse
Clone:	10F628 (7E2)
Isotype:	IgG2b
Immunogen:	Recombinant protein corresponding to C-terminus of human Achaete Scute homolog 2 (His-tagged).
Application:	ICC, ChIP, WB

Overview
Datasheets

Description

Description: Achaete Scute homolog 2 (also known as mammalian aschaete-scute homolog 2 or Mash2) is a nuclear protein expressed specifically in the extravillous trophoblasts of developing placenta. Placental development involves control by the basic helix-loop-helix transcription factor Achaete Scute homolog 2, which may regulate HIF (hypoxia) in the formation of spongiotrophoblasts. Targeted mutagenesis of Achaete Scute homolog 2 yielded loss of function results in embryonic lethality at midgestation due to placental failure associated with a lack of spongiotrophoblasts and reduced labyrinthine trophoblast layers. In addition to healthy placental development, Achaete Scute proteins may also be involved in the determination of neuronal precursors in the central and peripheral nervous systems. Achaete Scute homolog 2 has also been implicated as a controller of intestinal stem cell fate and is essential for the maintenance of adult intestinal stem cells.

Additional Text

Accession Number

NP_005161.1

Gene Name

ASCL2

Uniprot ID

Q99929

Specificity

Recognizes human Achaete Scute homolog 2 at ~20kD.

Purification

Protein G purified

Gene ID

430

Antibody Clonality

Monoclonal

A3619-81-FITC Datasheet

Price

£1,039.00

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