ATPase alpha 3, Na, K (Azide & BSA-Free)
Catalogue Number: A4000-65C1-USB
| Manufacturer: | United States Biological |
| Preservative: | Azide & BSA-Free |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 1 mg |
| Host name: | Mouse |
| Clone: | 8J327 |
| Isotype: | IgG1 |
| Immunogen: | Canine cardiac microsomes. Marker: Plasma membrane |
| Application: | FC, ICC, IF, WB, IHC, NT |
Description
Description: The sodium/potassium ATPase is an integral membrane enzyme found in all cells of higher organisms and is responsible for the ATP-dependent transport of sodium and potassium across the cell membrane. This membrane-bound enzyme is related to a number of other ATPases including sarcoplasmic and endoplasmic reticulum calcium ATPase (SERCA) and plasma membrane calcium ATPase (PMCA). The sodium/potassium ATPase consists of a large, multipass, transmembrane catalytic subunit, termed the alpha subunit, and an associated smaller glycoprotein, termed the beta subunit. Studies indicate that there are three isoforms of the alpha subunit (alpha 1, alpha 2, alpha 3) and two isoforms of the beta subunit (beta 1 and beta 2) encoded by two multigene families. The different isoforms of the sodium/potassium ATPase exhibit tissue-specific and developmental patterns of expression. The alpha 1 and beta mRNAs are present in all cell types examined, whereas the alpha 2 and alpha 3 mRNAs exhibit a more restricted pattern of cell-specific expression. The alpha-3 subunit has been found in neuronal and to skeletal and cardiac muscle, lung and stomach tissues.
Additional Text
Gene Name
ATP1A3
Gene ID
478
Uniprot ID
P13637
Purification
Protein A purified
Antibody Clonality
Monoclonal
A4000-65C1 Datasheet
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