Axin1 (AXIN1, AXIN, Axis Inhibition Protein 1, MGC5231) (MaxLight 650)
Catalogue Number: A4747-01-ML650-USB
| Manufacturer: | United States Biological |
| Physical state: | Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight™650. |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Alias: | AI316800|Axin|axin-1|axis inhibition protein 1|Fu|fused|Kb|Ki|kinky|knobbly|protein Fused |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul |
| Host name: | Mouse |
| Clone: | 10F631 (A5) |
| Isotype: | IgG2a, kappa |
| Immunogen: | GST-tagged recombinant protein corresponding to the N-terminus of mouse Axin-1. Species Sequence Homology: mouse |
| Application: | IP, WB |
Description
Description: MaxLight™650 is a new Far-IR stable dye conjugate comparable to Alexa Fluor™647, DyLight™649, Cy5™ and offers better labeling efficiency, brighter imaging and increased immunodetection. Absorbance (655nm); Emission (676nm); Extinction Coefficient 250,000. Axin-1 is constitutively expressed and acts as a negative regulator of Wnt expression. It has been demonstrated that mouse Wnt, Wnt3a, is secreted by multiple cell lines and can act and as a growth factor for stem cells. Secreted Wnt3a is highly hydrophobic because it is palmitoylated on an essential cysteine C77; the palmitoylated state of Wnt3a is essential for stem cell signaling. Incubation of stem cells with Wnt3a in tissue culture medium resulted in the increased number of mouse hematopoietic stem cells expressing "primitive" phenotype.
Additional Text
Accession Number
NP_033863.2
Gene Name
AXIN1
Specificity
Recognizes human Axin-1.
Purification
Protein G purified
Gene ID
12005
Uniprot ID
O35625
Antibody Clonality
Monoclonal
A4747-01-ML650 Datasheet
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