Anti-Human Amyloid-β (Lecanemab) - Fc Muted™
Catalogue Number: A495-LET
| Manufacturer: | Leinco Technologies, Inc |
| Type: | Recombinant Monoclonal |
| Shipping Condition: | Blue Ice |
| Unit(s): | 500 ug |
| Host name: | |
| Clone: | BAN-2401 |
| Isotype: | |
| Immunogen: | |
| Application: | ELISA |
Description
Description: Amyloid-β (Aβ) is a peptide that accumulates in the brains of individuals with Alzheimer's disease, forming plaques that are a hallmark of the condition. These plaques are believed to contribute to the neurodegenerative processes seen in Alzheimer's by disrupting cell function and triggering inflammatory responses. Amyloid-β is derived from the amyloid precursor protein (APP) through enzymatic cleavage. The aggregation of Aβ into oligomers and fibrils is a key pathological feature of Alzheimer's disease, making it a significant target for therapeutic interventions aimed at reducing or preventing plaque formation1,2. Known as clone BAN-2401, Lecanemab is the humanized IgG1 version of the mouse monoclonal antibody mAb158, specifically engineered to selectively bind to large, soluble Aβ protofibrils. BAN-2401 has shown efficacy in reducing Aβ protofibrils in the brain and cerebrospinal fluid (CSF) of animal models. In clinical trials, it has exhibited potential as a disease-modifying treatment for Alzheimer's disease. Additionally, BAN-2401 has been utilized in preclinical research to study its binding to Aβ deposits in postmortem brain sections from individuals with Down's syndrome3,4.
Additional Text
Concentration
5 mg/ml
Antibody Clonality
Monoclonal, Recombinant Monoclonal
Storage Note
Functional grade biosimilar antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.
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DELIVERY
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