Ritonavir
Catalogue Number: A8203-APE
| Manufacturer: | Apexbio |
| Physical state: | A solid |
| Type: | Protease Inhibitors |
| Alias: | Abbott 84538, ABT-538,Ritonavir |
| Shipping Condition: | Blue Ice |
| Unit(s): | 10 mg, 10 mM (in 1mL DMSO), 100 mg, 25 mg, 50 mg, SAMPLE |
Description
Description: Ritonavir, previously known as ABT-538, is a potent inhibitor of human immunodeficiency virus type 1 (HIV-1) protease that exhibits potent in vitro inhibition against HIV-1 strain as well as HIV-2 strain with 50% effective concentration EC50 values of 0.022 µM and 0.16 µM respectively. Ritonavir binds to the HIV-1 protease inactivating its function to cleave the Gag and Gag-Pol polyproteins into the core proteins and viral enzymes, which results in the formation of noninfectious viral particles. X-ray crystallographic analysis reveals a hydrophobic cluster between the isopropyl substituent on the P3 thiazolyl group of ritonavir and the side chains of Pro-81 and Val-82 of HIV-1 protease within the complex of ritonavir/HIV-1 protease.ReferenceKempf DJ, Marsh KC, Denissen JF, McDonald E, Vasavanonda S, Flentge CA, Green BE, Fino L, Park CH, Kong XP, et al. ABT-538 is a potent inhibitor of human immunodeficiency virus protease and has high oral bioavailability in humans. Proc Natl Acad Sci U S A. 1995 Mar 28;92(7):2484-8.Markowitz M, Saag M, Powderly WG, Hurley AM, Hsu A, Valdes JM, Henry D, Sattler F, La Marca A, Leonard JM, et al. A preliminary study of ritonavir, an inhibitor of HIV-1 protease, to treat HIV-1 infection. N Engl J Med. 1995 Dec 7;333(23):1534-9.
Additional Text
Storage Note
Store at -20°C
Short Description
HIV Protease Inhibitor
Reagent:Smile String
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Solubility
≥26 mg/mL in DMSO with gentle warming; insoluble in H2O; ≥9.02 mg/mL in EtOH
A8203 Datasheet
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