Darunavir
Catalogue Number: A8206-APE
| Manufacturer: | Apexbio |
| Physical state: | A solid |
| Type: | Protease Inhibitors |
| Shipping Condition: | Blue Ice |
| Unit(s): | 10 mM (in 1mL DMSO), 5 mg, 50 mg, SAMPLE |
Description
Description: Darunavir is an orally-bioavailable non-peptidic inhibitor of human immunodeficiency virus type 1 (HIV-1) protease that selectively inhibits HIV-1 protease enzyme induced cleavage of gag and gag-pol poly-proteins preventing the maturation of virions and also inhibits the dimerization of HIV-1 protease suppressing proteolytic activity and subsequent replication of HIV-1. Study results have shown that darunavir exhibits potent inhibition against HIV-1 with a value of 50% inhibition concentration IC50 of 0.003 µmol/L in HIV-1 infected MT-2 cells. Darunavir binds to HIV-1 protease with considerably high affinity and fits closely with the substrate envelop leading to its potent ability to inhibit multidrug-resistant HIV strains.ReferenceMcKeage K, Perry CM, Keam SJ. Darunavir: a review of its use in the management of HIV infection in adults. Drugs. 2009;69(4):477-503. doi: 10.2165/00003495-200969040-00007.
Additional Text
Storage Note
Store at -20°C
Short Description
HIV-1 protease inhibitor
Solubility
≥22.65 mg/mL in DMSO; insoluble in H2O; ≥4.94 mg/mL in EtOH with ultrasonic
Reagent:Smile String
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A8206 Datasheet
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