Anti-CD8 alpha/Lyt-2 [YTS 169.4]
Catalogue Number: AB00166-23.0-ABA
| Manufacturer: | Vector Laboratories, Inc (ABA) |
| Type: | Recombinant Monoclonal |
| Alias: | Leu2; CD8; CD8A; CD8a molecule; CD8a antigen; Leu2 T-lymphocyte antigen; Lyt-2; Lyt2OKT8; p32T-cell antigen Leu2; T-cell antigen; T cell co-receptor; T-cell surface glycoprotein CD8 alpha chain; T-cell surface glycoprotein Lyt-2; T8 T-cell antigen |
| Shipping Condition: | Blue Ice |
| Unit(s): | 200 ug |
| Host name: | Rabbit |
| Clone: | YTS 169.4 |
| Isotype: | IgG |
| Immunogen: | Murine CD8 (Lyt-2). |
| Application: | FC, IHC-Fr, IHC, Depl, InVivoA |
Additional Text
Gene Name
CD8A
Gene ID
12525
Uniprot ID
P01731
Purification
Purified
Antibody Clonality
Recombinant Monoclonal
Storage Note
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Application Notes
The antibody has been shown to show depleting activity in vivo. Mice have two alleles for CD8, Lyt2.1, and Lyt2.2, which are restricted to certain mouse strains. Lyt2.1, for example, is expressed in the mouse strains CBA, AKR, C3H, and DBA, whereas Lyt2.2 is expressed in the mouse strains BALB/c and C57BL/6 (B/6). YTS 169.4 was originally raised against CBA mouse thymocytes. However, there are publications in which it has been used in C57BL/6 and BALB/c mice, wherein it was used specifically as a pan-reactive Lyt2 reagent (Tavare et al., 2014; PMID: 24390540).
Short Description
This chimeric rabbit antibody was made using the variable domain sequences of the original Rat IgG2b format, for improved compatibility with existing reagents, assays and techniques.
AB00166-23.0 Datasheet
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