Anti-IL-2R alpha (CD25) [Basiliximab]

Catalogue Number: AB00188-35.0-BT-ABA

Manufacturer:	Vector Laboratories, Inc (ABA)
Type:	Recombinant Monoclonal
Alias:	Interleukin-2 receptor subunit alpha; IL-2 receptor subunit alpha; IL-2R subunit alpha; IL-2-RA; IL2-RA; TAC antigen; p55; CD25.
Shipping Condition:	Blue Ice
Unit(s):	1 mg
Host name:	Cyno monkey
Clone:	Basiliximab
Isotype:	IgG1
Immunogen:	Basiliximab was prepared by immunizing BALB/c mice with CTC 16 cells.
Application:	FC, IF, WB, IHC, Blk

Overview
Datasheets

Additional Text

Gene Name

IL2RA

Gene ID

3559

Uniprot ID

P01589

Purification

Purified

Antibody Clonality

Recombinant Monoclonal

Storage Note

Store at 4⁰C for up to 3 months. Note, this antibody is provided without added preservatives, it is therefore recommed this antibody be handled under sterile conditions. For longer storage, aliquot and store at -20⁰C.

Application Notes

Basiliximab is derived from the murine anti-Tac antibody. For the clinically used format, the variable regions from this antibody were grafted onto the sequence of the human IgG1κ constant regions. Basiliximab binding to CD25 competitively blocks the interaction of IL-2R with its ligand IL-2 on the surface of T cells. Blocking this interaction prevents T cell replication and T cell-mediated B cell activation. Basiliximab binding suppresses the immune system inhibits the pathway activating the cellular immune response to allograft rejection. IL-2 signalling suppression can additionally prevent acute graft-versus-host disease, autoimmune disorders and malignancies such as T cell leukemias (Binder et al, 2007). Basiliximab has also been used in FC, IF, IHC and WB studies, which enables the detection of CD25.

Short Description

This chimeric cynomolgus monkey antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.

AB00188-35.0-BT Datasheet

Price

£1,655.00

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