Anti-CD4 [MT310]
Catalogue Number: AB00217-26.0-ABA
| Manufacturer: | Vector Laboratories, Inc (ABA) |
| Type: | Recombinant Monoclonal |
| Alias: | Leu3/T3; T-cell differentiation antigen; Ly-4; L3T4; T-cell surface antigen T4/Leu-3 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 200 ug |
| Host name: | Rhesus monkey |
| Clone: | MT310 |
| Isotype: | IgG1 |
| Immunogen: | |
| Application: | FC, IF, IHC-P, IP, Blk, Inh |
Additional Text
Gene Name
CD4
Gene ID
920
Uniprot ID
P01730
Purification
Purified
Antibody Clonality
Recombinant Monoclonal
Storage Note
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Application Notes
This antibody strongly inhibits HIV-1 gp120-binding to CD4, which blocks HIV infectivity of CD4+ T lymphocytes, as well as the binding of MHCII, which results in the block of T-cell activation (possibly leading to anergy induction) (Qin et al., 2001; PMID: n/a). Additionally, antibody binding to CD4 leads to GM-CSF, TNF-α and IL-10 induction. (TNF-α induction only occurs after 20 hours.)
Short Description
This chimeric rhesus macaque antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.
AB00217-26.0 Datasheet
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