Anti-CD28 [JJ316]
Catalogue Number: AB00284-8.4-ABA
| Manufacturer: | Vector Laboratories, Inc (ABA) |
| Type: | Recombinant Monoclonal |
| Alias: | TP44; T-cell-specific surface glycoprotein CD28 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 200 ug |
| Host name: | Rat |
| Clone: | JJ316 |
| Isotype: | IgG2b |
| Immunogen: | Made by immunizing BALB/c mice with rat CD28 cDNA-transfected A20/J cells. |
| Application: | FC, IF, IHC, Agon, Stim-Co |
Additional Text
Gene Name
CD28
Gene ID
25660
Purification
Purified
Uniprot ID
P31042
Antibody Clonality
Recombinant Monoclonal
Storage Note
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Application Notes
This antibody binds rat CD28 and can convey as a co-stimulatory signal. At 100-1000-fold higher concentration than required for co-stimulation JJ316 (unlike the clone JJ319 marketed by competitors (see Tacke et al. 1997)) can induce proliferation of all T-cell subsets without TCR engagement.
Short Description
This is a chimeric antibody, created to reduce immunogenicity during in vivo applications, that does not bind complement or Fc-receptors.
AB00284-8.4 Datasheet
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