Anti-CD28 [1C6]
Catalogue Number: AB00472-202.1-ABA
| Manufacturer: | Vector Laboratories, Inc (ABA) |
| Type: | Recombinant Monoclonal |
| Alias: | TP44; Costimulatory molecule B7 receptor CD28; T-cell costimulatory molecule CD28 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 200 ug |
| Host name: | Dog |
| Clone: | 1C6 |
| Isotype: | IgG4 |
| Immunogen: | Canine CD28. |
| Application: | ELISA, FC, FA, Blk, InVivoA, Act |
Additional Text
Purification
Purified
Antibody Clonality
Recombinant Monoclonal
Storage Note
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
UniProt ID
Q9N0N8
Application Notes
This antibody exhibits an antagonistic activity, blocking mixed lymphocyte reactions and cytotoxic T lymphocyte-mediated killing. The use of this antibody to neutralize the CD26 signal following T-cell receptor activation is of clinical importance for transplantation therapy, as it has been shown to prevent graft rejection and graft-versus-host disease in the canine model of allogeneic hematopoietic cell transplantation (HCT). Interestingly, this antibody also exhibits agnostic activity; it was coated onto magnetic beads and used for the activation of canine peripheral blood lymphocytes (Szopa et al., 2021; PMID: 33679741).
Short Description
This chimeric dog antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.
AB00472-202.1 Datasheet
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