Anti-Digoxin [26 / 10]

Catalogue Number: AB00494-10.7-BT-ABA

Manufacturer:	Vector Laboratories, Inc (ABA)
Type:	Recombinant Monoclonal
Alias:	Digitalis
Shipping Condition:	Blue Ice
Unit(s):	1 mg
Host name:	Human
Clone:	26 / 10
Isotype:
Immunogen:	Spleen cells from A/J mice immunized with digoxin coupled to human serum albumin (Dig-HSA).
Application:	ELISA, RIA, Crstion

Overview
Datasheets

Additional Text

Purification

Purified

Antibody Clonality

Recombinant Monoclonal

Storage Note

Store at 4⁰C for up to 3 months. Note, this antibody is provided without added preservatives, it is therefore recommed this antibody be handled under sterile conditions. For longer storage, aliquot and store at -20⁰C.

Short Description

This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG2a format, for improved compatibility with existing reagents, assays and techniques.

Application Notes

The antibody is specific for digoxin, a cardiac glycoside derived from the foxglove plant. Digoxin is administered for the therapeutic treatment of heart conditions such as atrial fibrillation, atrial flutter and heart failure, an acts by inhibiting the Na+/K+ ATPase. However, the drug has a very narrow therapeutic index and can cause toxic side effects. The Fab fragment prepared from 26-10 that neutralises the activity of digoxin and can be used as an antidote in case of overdose of digitalis. Anti-digoxin monoclonal antibodies can also be used to measure serum levels of the drug as a guide to therapy, and are useful in the investigation of the kinetics of interaction between antibody and antigen (Mudgett-Hunter et al., 1985; PMID: 4033667). The structure of the Fab fragment of the antibody was determined by XRD crystallography (Jeffrey et al., 1993; PMID: 8234291).

AB00494-10.7-BT Datasheet

Price

£1,910.00

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