Anti-CD4 [YKIX302.9]
Catalogue Number: AB00594-201.1-BT-ABA
| Manufacturer: | Vector Laboratories, Inc (ABA) |
| Type: | Recombinant Monoclonal |
| Alias: | Leu3/T4; T-cell surface antigen T4/Leu-3; T-cell surface glycoprotein CD4 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 1 mg |
| Host name: | Dog |
| Clone: | YKIX302.9 |
| Isotype: | IgG2 |
| Immunogen: | This antibody was prepared by immunizing rats with concanavilin A activated T-cell blasts |
| Application: | FC, IHC-Fr, IHC |
Additional Text
Gene Name
CD4
Uniprot ID
P33705
Gene ID
403931
Purification
Purified
Antibody Clonality
Recombinant Monoclonal
Storage Note
Store at 4⁰C for up to 3 months. Note, this antibody is provided without added preservatives, it is therefore recommed this antibody be handled under sterile conditions. For longer storage, aliquot and store at -20⁰C.
Application Notes
This antibody recognizes canine CD4, which binds MHC II, and has been shown to block MHC II-dependent T cell responses in vivo and in vitro. In a canine transplant model, administration of this antibody has been demonstrated to partially deplete circulating T lymphocytes, but alone was not sufficient to prolong allograft survival (Watson, 1993). This antibody is one of a panel of anti-canine monoclonal antibodies can be used in the evaluation of leukemic status in dogs. This antibody has been used in IF and IP analysis to identify the canine homologue of human CD4 (Cobbold, 1994).
Short Description
This chimeric dog antibody was made using the variable domain sequences of the original Rat IgG2a format, for improved compatibility with existing reagents, assays and techniques.
AB00594-201.1-BT Datasheet
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