Anti-CD8A [YCATE55.9]

Catalogue Number: AB00601-202.1-ABA

Manufacturer:	Vector Laboratories, Inc (ABA)
Type:	Recombinant Monoclonal
Alias:	LEU2; T-cell surface glycoprotein CD8 alpha chain; CD8a
Shipping Condition:	Blue Ice
Unit(s):	200 ug
Host name:	Dog
Clone:	YCATE55.9
Isotype:	IgG4
Immunogen:	This antibody was prepared by immunizing rats with canine leucocytes, thymocytes or concanavalin A-activated lymphoblasts.
Application:	FC, IF, IHC-Fr, Blk, CMLA, MLR

Overview
Datasheets

Additional Text

Gene Name

CD8A

Gene ID

403157

Purification

Purified

Uniprot ID

P33706

Antibody Clonality

Recombinant Monoclonal

Storage Note

Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.

Application Notes

This antibody recognizes canine CD8α, and has been used in in IF and IHC studies to establish that CD8 expression is confined to a minority population of T cells, as is the case for other species (Cobbold, 1994). In a canine transplant model, administration of this antibody, in combination with another anti-CD8 antibody (YCATE60.3.9) causes a 90 per cent depletion of CD8+ T cells from the peripheral blood, but does not result in prolonged allograft survival (Watson, 1993). However, the administration of this antibody in combination with an anti-CD4 antibody is associated with an immunosuppressive effect, and an extended median graft survival time. This antibody blocks MHC class I dependant T-cell responses in vitro and in vivo.

Short Description

This chimeric dog antibody was made using the variable domain sequences of the original Rat IgG1 format, for improved compatibility with existing reagents, assays and techniques.

AB00601-202.1 Datasheet

Price

£385.00

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