Anti-CD8A [YCATE55.9]
Catalogue Number: AB00601-6.1-BT-ABA
| Manufacturer: | Vector Laboratories, Inc (ABA) |
| Type: | Recombinant Monoclonal |
| Alias: | LEU2; T-cell surface glycoprotein CD8 alpha chain; CD8a |
| Shipping Condition: | Blue Ice |
| Storage Condition: | 2-8°C |
| Unit(s): | 1 mg |
| Host name: | Rat |
| Clone: | YCATE55.9 |
| Isotype: | IgG1 |
| Immunogen: | This antibody was prepared by immunizing rats with canine leucocytes, thymocytes or concanavalin A-activated lymphoblasts. |
| Application: | FC, IF, IHC-Fr, Blk, CMLA, MLR |
Additional Text
Gene Name
CD8A
Gene ID
403157
Purification
Purified
Uniprot ID
P33706
Antibody Clonality
Recombinant Monoclonal
Storage Note
Store at 4⁰C for up to 3 months. Note, this antibody is provided without added preservatives, it is therefore recommed this antibody be handled under sterile conditions. For longer storage, aliquot and store at -20⁰C.
Application Notes
This antibody recognizes canine CD8α, and has been used in in IF and IHC studies to establish that CD8 expression is confined to a minority population of T cells, as is the case for other species (Cobbold, 1994). In a canine transplant model, administration of this antibody, in combination with another anti-CD8 antibody (YCATE60.3.9) causes a 90 per cent depletion of CD8+ T cells from the peripheral blood, but does not result in prolonged allograft survival (Watson, 1993). However, the administration of this antibody in combination with an anti-CD4 antibody is associated with an immunosuppressive effect, and an extended median graft survival time. This antibody blocks MHC class I dependant T-cell responses in vitro and in vivo.
AB00601-6.1-BT Datasheet
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