Anti-RSV [RSHZ19 (Felvizumab)]
Catalogue Number: AB00729-49.0-ABA
| Manufacturer: | Vector Laboratories, Inc (ABA) |
| Type: | Recombinant Monoclonal |
| Alias: | SB 209763; respiratory syncytial virus |
| Shipping Condition: | Blue Ice |
| Unit(s): | 50 ug |
| Host name: | Ferret |
| Clone: | RSHZ19 (Felvizumab) |
| Isotype: | IgM |
| Immunogen: | This antibody was prepared by the humanization of an F protein-specific murine MAb, RSV19. More specifically, molecular techniques were used to insert the complementarity determining regions from murine RSV19 into a human IgG1 heavy and k light chain-variable domain framework. |
| Application: | ELISA, FA |
Additional Text
Purification
Purified
Antibody Clonality
Recombinant Monoclonal
Storage Note
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Application Notes
Though shown to be safe and well-tolerated (Everitt, 1996) and protective against RSV infection in BALB/c mice and cotton rats (Wyde, 1995), this antibody did not demonstrate efficacy in a Phase 3 study (Reichert, 2008). In in vitro studies, palivizumab, another humanized Mab specific for the F protein of RSV, was 4 to 5-fold more potent than felvizumab in neutralising RSV (Scott, 1999).
Short Description
This chimeric ferret antibody was made using the variable domain sequences of the original humanized Mouse format, for improved compatibility with existing reagents, assays and techniques.
AB00729-49.0 Datasheet
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