Anti-CD64 [H22]
Catalogue Number: AB00731-1.4-ABA
| Manufacturer: | Vector Laboratories, Inc (ABA) |
| Type: | Recombinant Monoclonal |
| Alias: | FcγRI; High affinity immunoglobulin gamma Fc receptor I; IgG Fc receptor I; Fc-gamma RI; FcRI; Fc-gamma RIA |
| Shipping Condition: | Blue Ice |
| Unit(s): | 200 ug |
| Host name: | Mouse |
| Clone: | H22 |
| Isotype: | IgG1 |
| Immunogen: | The original antibody was generated by cloning a single-chain fragment (scFv) derived from the murine anti-human CD64 monoclonal antibody (mAb) clone "m22". Clone m22 was originally described by Guyre et al. (1989). |
| Application: | ELISA, FC, Cmpt |
Additional Text
Gene ID
2209
Gene Name
FCGR1A
Uniprot ID
P12314
Purification
Purified
Antibody Clonality
Recombinant Monoclonal
Storage Note
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Short Description
This is a reformatted Fc Silent™ chimeric mouse IgG1 antibody based on the original human IgG1 antibody, created for improved compatibility with existing reagents, assays, and techniques.
Application Notes
This antibody can be bound to a toxin so that it displays specific cytotoxicity and thus can be used to eliminate AML cells selectively. This antibody was bound to a truncated version of the Pseudomonas exotoxin A (ETA'). The binding activity of the VH/VL antibody format was unaffected by the fusion of the m22(scFv) coding regions to the ETA' coding sequences. FC analysis indicated that this immunotoxin drove 41% of primary leukemia cells from a patient with CD64-positive AML into early apoptosis (Tur et al., 2003; PMID: 14679004). Similarly, in an in vivo mouse model, IHC analysis revealed efficient elimination of human CD64+ tumor cells in mouse organs (Tur et al., 2011; PMID: 21077160).
AB00731-1.4 Datasheet
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