Anti-DR5 [PRO95780 (Drozitumab)]

Catalogue Number: AB00740-15.0-BT-ABA

Manufacturer:	Vector Laboratories, Inc (ABA)
Type:	Recombinant Monoclonal
Alias:	CD262; death receptor 5; TRAIL receptor 2; TRAILR2; tumor necrosis factor receptor superfamily member 10B; TNFRSF10B; apomab
Shipping Condition:	Blue Ice
Unit(s):	500 ug
Host name:	Human
Clone:	PRO95780 (Drozitumab)
Isotype:	IgM
Immunogen:	The variable domains of this antibody were derived as scFv from a human antibody phage display library, with biotinylated DR5-Fc used to capture DR5-specific phage. The scFv obtained were subsequently reformatted into full-length antibodies.
Application:	ELISA, IF, IP, IB, Agon

Overview
Datasheets

Additional Text

Gene Name

TNFRSF10B

Uniprot ID

O14763

Gene ID

8795

Purification

Purified

Antibody Clonality

Recombinant Monoclonal

Storage Note

Store at 4⁰C for up to 3 months. Note, this antibody is provided without added preservatives, it is therefore recommed this antibody be handled under sterile conditions. For longer storage, aliquot and store at -20⁰C.

Application Notes

This antibody binds DR5, triggering DR5 clustering and DISC activation in a range of cancer cells, including colorectal cancer and NSCLC cells (Adams, 2009). Conversely, this antibody showed no effector caspase activation or cell death induction in normal human hepatocytes. In vivo, this antibody has been shown to inhibit tumor xenograft growth in a variety of animal models (Varfolomeev, 2009). This antibody was used in IP, immunoblot, ELISA and IF analysis to precisely characterise its interaction with the DR5 ligand (Adams, 2009).

Short Description

This reformatted human antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.

AB00740-15.0-BT Datasheet

Price

£2,215.00

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