Anti-Glycoprotein H [A13-d6.3]

Catalogue Number: AB00772-10.6-ABA

Manufacturer:Vector Laboratories, Inc (ABA)
Type:Recombinant Monoclonal
Alias:d6.3; gH; Envelope glycoprotein H
Shipping Condition:Blue Ice
Unit(s): 100 ug
Host name: Human
Clone: A13-d6.3
Isotype:
Immunogen: d6.3 was generated by immunizing mice with PrV.
Application: NT, IS, Crstion

Additional Text

Purification

Purified

Antibody Clonality

Recombinant Monoclonal

Storage Note

Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.

Uniprot ID

A0A142I9U7

Application Notes

d6.3 neutralizes the ΔgL-Pass PrV variant of PrV and can stain ΔgL-Pass PrV variant but not the wild-type PrV by immunostaining. The epitope of d6.3 is not blocked by the formation of the gH/gL heterodimer. The d6.3Fab fragment (obtained through papain digestion) can be complexed with the core fragment of the PrV glycoprotein H (gH) ectodomain (aa 107-639) for structural studies by crystallography.

Short Description

This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG2b format, for improved compatibility with existing reagents, assays and techniques.