Anti-Lymphotoxin alpha [MLTA3698A (Pateclizumab)]
Catalogue Number: AB00773-10.0-ABA
| Manufacturer: | Vector Laboratories, Inc (ABA) |
| Type: | Recombinant Monoclonal |
| Alias: | LTα; LT-alpha; TNF-beta; Tumor necrosis factor ligand superfamily member 1 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 200 ug |
| Host name: | Human |
| Clone: | MLTA3698A (Pateclizumab) |
| Isotype: | IgG1 |
| Immunogen: | This humanized antibody was derived from a mouse anti-human LT-α hybridoma mAb. |
| Application: | FC, Blk, Depl, SPR |
Additional Text
Uniprot ID
P01374
Gene Name
LTA
Gene ID
4049
Purification
Purified
Antibody Clonality
Recombinant Monoclonal
Storage Note
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Application Notes
This antibody has been shown to able to both block LTα-mediated signaling and selectively deplete LTα-expressing activated T and B cells, which has therapeutic applications in abrogating proinflammatory responses in rheumatoid arthritis (RA) pathology (Kennedy, 2014). Preliminary clinical trials demonstrated that administration of this antibody decreased serum levels of CXCL13, a biomarker of RA disease activity (Emu, 2012). In a phase II trial, this antibody had a trend for clinical effects on the symptoms of RA after 3 months of treatment, but the differences from placebo responses were not statistically significant (Kennedy, 2014). In a human peripheral blood mononuclear cell transplanted SCID mouse model of graft-versus-host disease, this antibody specifically depleted activated LTα-expressing human donor T and B cells, prolonging survival of the mice (Chiang, 2012). Finally, this antibody has been used to in FC and surface plasmon resonance analysis to characterise its interaction with the LTα ligand.
AB00773-10.0 Datasheet
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