Anti-Lymphotoxin alpha [MLTA3698A (Pateclizumab)]

Catalogue Number: AB00773-10.0-BT-ABA

Manufacturer:	Vector Laboratories, Inc (ABA)
Type:	Recombinant Monoclonal
Alias:	LTα; LT-alpha; TNF-beta; Tumor necrosis factor ligand superfamily member 1
Shipping Condition:	Blue Ice
Unit(s):	1 mg
Host name:	Human
Clone:	MLTA3698A (Pateclizumab)
Isotype:	IgG1
Immunogen:	This humanized antibody was derived from a mouse anti-human LT-α hybridoma mAb.
Application:	FC, Blk, Depl, SPR

Overview
Datasheets

Additional Text

Uniprot ID

P01374

Gene Name

LTA

Gene ID

4049

Purification

Purified

Antibody Clonality

Recombinant Monoclonal

Storage Note

Store at 4⁰C for up to 3 months. Note, this antibody is provided without added preservatives, it is therefore recommed this antibody be handled under sterile conditions. For longer storage, aliquot and store at -20⁰C.

Application Notes

This antibody has been shown to able to both block LTα-mediated signaling and selectively deplete LTα-expressing activated T and B cells, which has therapeutic applications in abrogating proinflammatory responses in rheumatoid arthritis (RA) pathology (Kennedy, 2014). Preliminary clinical trials demonstrated that administration of this antibody decreased serum levels of CXCL13, a biomarker of RA disease activity (Emu, 2012). In a phase II trial, this antibody had a trend for clinical effects on the symptoms of RA after 3 months of treatment, but the differences from placebo responses were not statistically significant (Kennedy, 2014). In a human peripheral blood mononuclear cell transplanted SCID mouse model of graft-versus-host disease, this antibody specifically depleted activated LTα-expressing human donor T and B cells, prolonging survival of the mice (Chiang, 2012). Finally, this antibody has been used to in FC and surface plasmon resonance analysis to characterise its interaction with the LTα ligand.

AB00773-10.0-BT Datasheet

Price

£1,655.00

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