Anti-Parathyroid Hormone-related Protein [23-57-137-1]

Catalogue Number: AB00795-10.3-BT-ABA

Manufacturer:	Vector Laboratories, Inc (ABA)
Type:	Recombinant Monoclonal
Alias:	PTHrP; PTH-rP; Parathyroid hormone-like protein; PLP; PTHrP[1-34]
Shipping Condition:	Blue Ice
Unit(s):	1 mg
Host name:	Human
Clone:	23-57-137-1
Isotype:	IgG1
Immunogen:	The anti-PTHrP antibody was prepared by immunizing mice with synthetic human bovine thyroglobulin-conjugated PTHrP (aa 1-34) and generating the hybridoma cell line #23-57-137-1
Application:	NT, Crstion

Overview
Datasheets

Additional Text

Gene Name

PTHLH

Gene ID

5744

Uniprot ID

P12272

Purification

Purified

Antibody Clonality

Recombinant Monoclonal

Storage Note

Store at 4⁰C for up to 3 months. Note, this antibody is provided without added preservatives, it is therefore recommed this antibody be handled under sterile conditions. For longer storage, aliquot and store at -20⁰C.

Application Notes

The antibody blocks the binding of PTHrP to parathyroid hormone receptor 1 through binding to a site closely overlapping with the receptor-interacting site at the extracellular loop and juxtamembrane regions. The antibody does not block the action of parathyroid hormone (PTH) through the same receptor. The antibody inhibits the action of PTHrP-(1-34) in promoting cAMP production by osteosarcoma cells by 90%,. The antibody also functions in vivo, and can treat nude mice rendered hypercalcemic by PAN-7-JCK cells, and prevents cachexia in mice bearing the LC6-JCK human lung cancer xenograft, independent of the calcium-lowering effect of the antibody. The fab fragment of this antibody, generated by papain digestion, has been used for cystallization of PTHrP at atomic level resolution.

Short Description

This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG format, for improved compatibility with existing reagents, assays and techniques.

AB00795-10.3-BT Datasheet

Price

£1,655.00

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Quantity
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