Anti-Botulinum neurotoxin type A [CR1]
Catalogue Number: AB00803-206.1-ABA
| Manufacturer: | Vector Laboratories, Inc (ABA) |
| Type: | Recombinant Monoclonal |
| Alias: | BoNT/A; BoNT; Botulinum neurotoxin; Bontoxilysin-A; Bontoxilysin A; BOTOX |
| Shipping Condition: | Blue Ice |
| Unit(s): | 0.1 mg |
| Host name: | Guinea Pig |
| Clone: | CR1 |
| Isotype: | IgG2 |
| Immunogen: | CR1 was produced by a yeast gene diversity library used to increase the affinitiy of scFv AR2 for BoNT/A2, while maintinaing high affinity binding to BoNT/A2. AR2 was generated after multiple rounds of affinity maturation of the humanized C25, which itself was created by CDR-grafting from the parental murine C25. Murine C25 was prepared by constructing a scFv phage display library from mice immunized with recombinant BoNT/A binding domain (Hc). |
| Application: | FC, NT |
Additional Text
Uniprot ID
P10845
Purification
Purified
Gene ID
5185061
Antibody Clonality
Recombinant Monoclonal
Gene Name
bont
Storage Note
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Application Notes
Antibody binding can be studied by FC and the antibody also shows in vivo neutralizing activity against botulinum neurotoxin - the neutralizing activity is increased when administered in combination with the human BoNT/A antibodies RAZ1 and 2G11.
Short Description
This chimeric guinea pig antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.
AB00803-206.1 Datasheet
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