Anti-CD72 [BU40]
Catalogue Number: AB00831-13.12-ABA
| Manufacturer: | Vector Laboratories, Inc (ABA) |
| Type: | Recombinant Monoclonal |
| Alias: | Lyb-2; B-cell differentiation antigen CD72 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 200 ug |
| Host name: | Human |
| Clone: | BU40 |
| Isotype: | IgG4 |
| Immunogen: | This antibody was raised against the HF B1 plasmacytoid cell line, which is considered to be late B-like. |
| Application: | FC, Act, Stim |
Additional Text
Gene Name
CD72
Gene ID
971
Uniprot ID
P21854
Purification
Purified
Antibody Clonality
Recombinant Monoclonal
Storage Note
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Application Notes
This antibody has been used to investigate cell-surface expression of CD72 in FACS analysis (Kataoka et al, 2013). This antibody has been shown to induce resting B cells to enter the G1 phase of the cell cycle, stimulate B cell expression of major histocompatibility complex class II antigen and potentiate the capacity of IL-4 to induce CD23 production (Katira et al, 1992). It also stimulates TNF-α and IL-6 production in CD14+ monocytes (Yoshida et al, 2015). Ligation of CD72 by this antibody has been observed to suppress the proliferation of an acute myelogenous leukaemia cell line (Kataoka et al, 2013).
Short Description
This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG2a format, for improved compatibility with existing reagents, assays and techniques.
AB00831-13.12 Datasheet
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