Anti-Factor VIII [RFF-VIII:c/8]

Catalogue Number: AB00870-13.12-BT-ABA

Manufacturer:	Vector Laboratories, Inc (ABA)
Type:	Recombinant Monoclonal
Alias:	AHF; Antihemophilic factor; coagulation factor VIII; procoagulant component; coagulation factor VIIIc; DXS1253E; F8C; factor VIII F8B; FVIII; HEMAF8B; Procoagulant component
Shipping Condition:	Blue Ice
Unit(s):	1 mg
Host name:	Human
Clone:	RFF-VIII:c/8
Isotype:	IgG4
Immunogen:	This antibody was raised by immunising BALB/C mice with highly purified procoagulant factor VIII (VIII: C). Spleen cells were then isolated from immunised mice, and fused with P3 NSI mouse myeloma cells to generate hybridomas.
Application:	WB, Blk, Depl

Overview
Datasheets

Additional Text

Gene Name

Uniprot ID

P00451

Gene ID

2157

Purification

Purified

Antibody Clonality

Recombinant Monoclonal

Storage Note

Store at 4⁰C for up to 3 months. Note, this antibody is provided without added preservatives, it is therefore recommed this antibody be handled under sterile conditions. For longer storage, aliquot and store at -20⁰C.

Application Notes

This antibody is a potent coagulation inhibitor (Rotblat, 1983).This antibody has been employed to produce factor VIII-deficient plasma by immunodepletion (Takase et al, 1987); purified monoclonal antibodies were bound to Sepharose columns, which were used to reduce the factor VII content of plasma through column chromatography. This antibody does not bind antigens if CRM negative haemophilic plasma, which lacks factor VIII, is used in column chromatography (Rotblat et al, 1983). This antibody has also been used in Western blotting to identify factor VIII (Rotblat et al, 1985)

Short Description

This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.

AB00870-13.12-BT Datasheet

Price

£1,655.00

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