Anti-acetylcholine receptor [mAb198]
Catalogue Number: AB00909-10.0-BT-ABA
| Manufacturer: | Vector Laboratories, Inc (ABA) |
| Type: | Recombinant Monoclonal |
| Alias: | nAchR; Neuronal acetylcholine receptor |
| Shipping Condition: | Blue Ice |
| Unit(s): | 1 mg |
| Host name: | Human |
| Clone: | mAb198 |
| Isotype: | IgG1 |
| Immunogen: | This antibody was raised by immunising rats with acetylcholine receptor derived from human skeletal muscle. |
| Application: | ELISA, IP, WB, IHC, Depl, Crstion |
Additional Text
Gene Name
CHRNA1
Uniprot ID
P02708
Gene ID
1134
Purification
Purified
Antibody Clonality
Recombinant Monoclonal
Storage Note
Store at 4⁰C for up to 3 months. Note, this antibody is provided without added preservatives, it is therefore recommed this antibody be handled under sterile conditions. For longer storage, aliquot and store at -20⁰C.
Application Notes
The specificity of this antibody for the major immunogenic region of human acetylcholine receptor has been confirmed in Western blot and ELISA analysis (Barchan et al, 1998). This antibody cross-links acetylcholine receptors on the muscle surface and promotes their degradation; incubation of AChR-expressing cell lines with mAb198 results in a reduction in AChR (Barchan et al, 1988). Indeed, administration of this antibody to mice is sufficient to induce experimental autoimmune myasthenia gravis (EAMG), a neuromuscular disorder arising from a reduction in available acetylcholine receptors at the NMJ (Asher, 1993).
Short Description
This chimeric human antibody was made using the variable domain sequences of the original Rat IgG2a format, for improved compatibility with existing reagents, assays and techniques.
AB00909-10.0-BT Datasheet
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