Anti-ectodysplasin A [EctoD2]

Catalogue Number: AB00912-1.1-ABA

Manufacturer:Vector Laboratories, Inc (ABA)
Type:Recombinant Monoclonal
Alias:O54693; Q92838; Ectodysplasin-A; EDA
Shipping Condition:Blue Ice
Unit(s): 200 ug
Host name: Mouse
Clone: EctoD2
Isotype: IgG1
Immunogen: This antibody was raised by immunising Eda-deficient Tabby mice with an active recombinant form of EDA1 (Fc-EDA1).
Application: ELISA, FC, SDS-PAGE, WB, Blk

Additional Text

Purification

Purified

Antibody Clonality

Recombinant Monoclonal

Storage Note

Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.

Application Notes

The specificity of this antibody for EDA has been confirmed in SDS-PAGE, Western blot, ELISA, native gel electrophoresis and FC experiments (Kowalczyk-Quintas et al, 2014). This antibody blocks mammalian and avian EDA1 and EDA2 from binding EDAR (Kowalczyk-Quintas et al, 2014). When administered to pregnant wild-type mice, this antibody induces foetal ectodermal dysplasia (Kowalczyk-Quintas et al, 2014). Therapeutically, this antibody may be useful in the treatment of disorders arising as a result of excessive EDA1 action.