Anti-Hepatitis A virus capsid [R10]
Catalogue Number: AB00933-2.0-ABA
| Manufacturer: | Vector Laboratories, Inc (ABA) |
| Type: | Recombinant Monoclonal |
| Shipping Condition: | Blue Ice |
| Unit(s): | 200 ug |
| Host name: | Mouse |
| Clone: | R10 |
| Isotype: | IgG2a |
| Immunogen: | This antibody was raised by immunising BALB/c mice intraperitoneally with inactivated Hepatitis A viruses. |
| Application: | ELISA, NT, Crstion |
Additional Text
Purification
Purified
Antibody Clonality
Recombinant Monoclonal
Storage Note
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Application Notes
This neutralising antibody blocks Hepatitis A virus attachment to host cell receptors and interferes with viral uncoating (Wang et al, 2017). This antibody recognises conformational epitopes by ELISA, but not linear epitopes in immunoblot analysis (Wang et al, 2017). A Fab derived from this antibody has been used to determine the structure of Hepatitis A viral particles, through both cryo-EM microscopy and X-ray crystallography (Wang et al, 2017).
Short Description
This reformatted mouse antibody was made using the variable domain sequences of the original Mouse IgG format, for improved compatibility with existing reagents, assays and techniques.
AB00933-2.0 Datasheet
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