Anti-Envelope protein (soluble) [Z3L1]
Catalogue Number: AB00940-13.12-ABA
| Manufacturer: | Vector Laboratories, Inc (ABA) |
| Type: | Recombinant Monoclonal |
| Alias: | ZIKV sE; Zika virus soluble envelope protein; Zika virus envelope protein; ZIKV soluble envelope protein; ZIKV envelope protein; Zika virus sE protein; ZIKV sE protein; Z3-L1 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 200 ug |
| Host name: | Human |
| Clone: | Z3L1 |
| Isotype: | IgG4 |
| Immunogen: | Anti-ZIKV mAbs were obtained from the sera and peripheral blood mononuclear cells of a ZIKV-infected patient. |
| Application: | ELISA, FC, NT, SPR, Crstion |
Additional Text
Purification
Purified
Antibody Clonality
Recombinant Monoclonal
Storage Note
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Application Notes
Z3L1 was confirmed to bind ZIKV sE protein by ELISA, with an affinity of 5.39 uM shown by SPR (Wang et al, 2016). Using a FACS-based assay, it was shown that Z3L1 was sufficient for complete neutralisation of viral activity against infected C6/36 and Vero cells. In vivo, it has been shown that Z3L1 protected IFN receptor KO mice from ZIKV infection.
Short Description
This reformatted human antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.
AB00940-13.12 Datasheet
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