Anti-BTLA [HMBT-6B2]

Catalogue Number: AB01027-2.3-VXX-ABA

Manufacturer:	Vector Laboratories, Inc (ABA)
Type:	Recombinant Monoclonal
Alias:	CD272; B and T lymphocyte attenuator; B- and T-lymphocyte attenuator; B and T lymphocyte associated protein; B- and T-lymphocyte-associated protein; BTLA1; FLJ16065; MGC129743
Shipping Condition:	Blue Ice
Unit(s):	25 mg
Host name:	Mouse
Clone:	HMBT-6B2
Isotype:	IgG2a
Immunogen:	This antibody was raised by immunising Armenian hamsters with mouse BTLA:Fc fusion protein.
Application:	FC, IP, WB, FA, Blk, IB

Overview
Datasheets

Additional Text

Gene Name

BTLA

Uniprot ID

Q7TSA3

Gene ID

208154

Antibody Clonality

Recombinant Monoclonal

Storage Note

All VivopureX products are formulated in PBS only without addition of preservatives. To ensure optimal storage and prevent microbial contamination, only open and dispense under sterile conditions.

Application Notes

This antibody has been used in immunoblot analyses to confirm that B and T lymphocyte attenuator (BTLA) regulates T cell activation through interaction with herpesvirus entry mediator (HVEM) (Sedy et al, 2005), as well as in FACS and yeast display technology to demonstrate that BTLA exhibits structural and expression polymorphisms and is highly induced in anergic CD4+ T Cells (Hurchla et al, 2005). In a mouse conjunctivitis model, treatment with this antibody during the induction phase has been shown to decrease B-cell population, upregulate Th2 cytokine production and increase the conjunctival eosinophile numbers (Ishida et al, 2012). However, treatment with this antibody during the effector phase does not affect the development of experimental conjunctivitis (Ishida et al, 2012).

Short Description

This chimeric mouse antibody was made using the variable domain sequences of the original Hamster IgG format, for improved compatibility with existing reagents, assays and techniques.

AB01027-2.3-VXX Datasheet

Price

£3,605.00

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