Anti-influenza [2-12C]

Catalogue Number: AB01105-10.0-ABA

Manufacturer:Vector Laboratories, Inc (ABA)
Type:Recombinant Monoclonal
Alias:H1N1; Influenza H1N1; Influenza A virus hemagglutinin glycoprotein; Influenza A virus HA; HA; hemagglutinin
Shipping Condition:Blue Ice
Unit(s): 200 ug
Host name: Human
Clone: 2-12C
Isotype: IgG1
Immunogen: This human 2-12C antibody was isolated from a donor that was exposed to A/California/07/2009 virus.
Application: ELISA, IF, MN, Haggl-Inh, VT

Additional Text

Purification

Purified

Antibody Clonality

Recombinant Monoclonal

Storage Note

Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.

Uniprot ID

C3W5X2

Application Notes

This 2-12C antibody was isolated from a donor that was exposed to A/California/07/2009 virus. It was used as a control antibody alongside with other mAbs in enzyme-linked immunosorbent, indirect immunofluorescent, virus titration, hemagglutination inhibition (HAI), and microneutralization (MN) assays for the assessment of the binding activity of HA head-specific and head cross-reactive antibodies on cells infected with the variant viruses, and for the subsequent mapping of the HA1 K163 residue in former H1N1 viruses (Huang et al., 2015). This 2-12C antibody was reported to select a variant virus with HA substitutions K130E and G170R and, to retain the capacity to neutralize clade 6B viruses at <10 ng/ml similar to the ferret antisera (Huang et al., 2015).