Anti-P-selectin [PL7-6]

Catalogue Number: AB01141-1.32-ABA

Manufacturer:Vector Laboratories, Inc (ABA)
Type:Recombinant Monoclonal
Alias:GMP-140; SELP; CD62 antigen-like family member P; Granule membrane protein 140; Leukocyte-endothelial cell adhesion molecule 3; LECAM3; Platelet activation dependent granule-external membrane protein; PADGEM; CD62P
Shipping Condition:Blue Ice
Unit(s): 100 ug
Host name: Mouse
Clone: PL7-6
Isotype: IgG1
Immunogen: This antibody was raised by immunising BALB/c mice with washed platelets.
Application: ELISA, FC, WB

Additional Text

Uniprot ID

P16109

Gene Name

SELP

Gene ID

6403

Purification

Purified

Antibody Clonality

Recombinant Monoclonal

Storage Note

Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.

Application Notes

This antibody has been used in flow cytometric detection of thrombin-stimulated platelets (Katayama et al, 1992), and a chimeric mouse/human version of this antibody also preferentially reacts with activated platelets (Kurome et al, 1994). This could enable the detection of platelets aggregating at sites of blood vessel injury, or the delivery of clot-dissolving drugs. The specificity of this antibody for CD62 has been confirmed in western blot and ELISA (Katayama et al, 1992), and ELISA analysis based on this antibody has been used to assess P-selectin levels in plasma sample of patients post-angina (Ikeda et al, 1995).

Short Description

This reformatted mouse antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.