Anti-FceR1 alpha [Mar-1]

Catalogue Number: AB01187-22.0-ABA

Manufacturer:	Vector Laboratories, Inc (ABA)
Type:	Recombinant Monoclonal
Alias:	Fcer1a; Fc epsilon RI alpha; FceRIa; FceRI alpha; FceRI-α; high affinity IgE receptor; High affinity immunoglobulin epsilon receptor subunit alpha;Fce1a; Fc-epsilon RI-alpha; FcERI; IgE Fc receptor subunit alpha
Shipping Condition:	Blue Ice
Unit(s):	200 ug
Host name:	Armenian Hamster
Clone:	MAR-1
Isotype:	IgG
Immunogen:
Application:	FC, IP, IHC, Depl

Overview
Datasheets

Additional Text

Gene Name

FCER1A

Gene ID

14125

Purification

Purified

Uniprot ID

P20489

Antibody Clonality

Recombinant Monoclonal

Storage Note

Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.

Application Notes

This antibody has been used in flow cytometric analysis of FceR1 alpha cell surface expression by basophils (Min et al, 2004; Chen et al, 2009), and immunohistochemical analysis of epidermal sheets (Holzmann et al, 2004). It has also been used in immunoprecipitation analysis of cell lysates from lung cDCs and MC/9 mast cells (Grayson et al, 2007). In vitro incubation of basophils with this antibody blocks subsequent MAR-1 staining, but does not activate basophil IL-4 production (Sokol et al, 2008). Intravenous treatment of mice with this antibody results in basophil depletion in peripheral blood, spleen, bone marrow and liver, but not skin or intraperitoneal mast cell depletion (Sokol et al, 2008). Following treatment with this antibody, basophil-depleted mice display impaired Th2 differentiation upon papain immunisation (Sokol et al, 2008). However, MAR-1 treated mice respond normally to high-dose intravenous Ig in both the K/BxN serum transfer arthritis and collagen-induced arthritis models, despite basophil depletion (Campbell et al, 2014).

AB01187-22.0 Datasheet

Price

£390.00

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