Anti-Cyclosporin A [R454511]
Catalogue Number: AB01221-23.0-ABA
| Manufacturer: | Vector Laboratories, Inc (ABA) |
| Type: | Recombinant Monoclonal |
| Alias: | CsA; ciclosporin A, cyclosporine A |
| Shipping Condition: | Blue Ice |
| Unit(s): | 200 ug |
| Host name: | Rabbit |
| Clone: | R454511 |
| Isotype: | IgG |
| Immunogen: | BALB/c mice were immunised with a D-Lys8-Cs derivative coupled to a carrier protein. |
| Application: | ELISA, Crstapy |
Additional Text
Purification
Purified
Antibody Clonality
Recombinant Monoclonal
Storage Note
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Application Notes
Mutagenesis of Cs-derivatives identified that R454511 binds to residues 1, 2, 3, 4, 5, 9 and 11 of CsA (Quesniaux et al., 1990). In ELISA experimenets, R454511 was found to bind to Cs conjugated with both Thr2 (Thr2-Cs-BSA) and Lys8 (D-Lys8-Cs-BSA) (Quesniaux et al., 1990). The crystal structure of R454511 in complex with CsA has been obtained to 2.65 Å resolution (Altschuh et al., 1992).
Short Description
This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.
AB01221-23.0 Datasheet
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