Anti-GPIIB/IIIA [PDG7]
Catalogue Number: AB01225-10.3-BT-ABA
| Manufacturer: | Vector Laboratories, Inc (ABA) |
| Type: | Recombinant Monoclonal |
| Alias: | glycoprotein IIb/IIIa; integrin αIIbβ3 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 1 mg |
| Host name: | Human |
| Clone: | PDG7 |
| Isotype: | IgG1 |
| Immunogen: | A phagemid library was constructed from the peripheral blood lymphocytes of a donor who was immunised with RhD+ red blood cells, and PDG7 was isolated after five rounds of affinity selection. |
| Application: | DB, Inh |
Additional Text
Purification
Purified
Antibody Clonality
Recombinant Monoclonal
Storage Note
Store at 4⁰C for up to 3 months. Note, this antibody is provided without added preservatives, it is therefore recommed this antibody be handled under sterile conditions. For longer storage, aliquot and store at -20⁰C.
Application Notes
Dot blots confirmed the specificity of PDG7 for GPIIB/IIIA. Inhibition assays were used to show that platelet-associated autoantibodies from AITP patients binds a closely related epitope to that of the recombinant anti-GPIIb/IIIa phage clones (Escher et al, 1998). Inhibition studies also confirmed that PDG7 inhibited binding of eluted platelet-associated autoantibodies from AITP patients to platelets (Escher et al, 1998).
Short Description
This reformatted human antibody was made using the variable domain sequences of the original Human Fab format, for improved compatibility with existing reagents, assays and techniques.
AB01225-10.3-BT Datasheet
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