Anti-Norovirus P domain [Nano-27]

Catalogue Number: AB01245-10.9-ABA

Manufacturer:	Vector Laboratories, Inc (ABA)
Type:	Recombinant Monoclonal
Shipping Condition:	Blue Ice
Unit(s):	200 ug
Host name:	Human
Clone:	Nano-27
Isotype:	IgG1
Immunogen:	An alpaca was injected with norovirus GII.10 virus-like particles (VLPs), and a phage display library constructed. Nano-27 was selected from this phage display library.
Application:	ELISA, NT, ITC, Crstapy

Overview
Datasheets

Additional Text

Gene Name

ORF2

Purification

Purified

Gene ID

1491972

Uniprot ID

Q83884

Antibody Clonality

Recombinant Monoclonal

Storage Note

Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.

Application Notes

The binding specificity of Nano-27 for the P domain of Norovirus strain GII.10 was confirmed using ELISA (Koromyslova et al, 2017). Using ITC the Kd of Nano-27 binding to the P domain of GII.10 was estimated as 9.50x10^-9 M (Koromyslova et al, 2017). The structure of Nano-27 in complex with G11.10 P domain was also obtained (Koromyslova et al, 2017). In neutralisation assays Nano-27 did not inhibit the binding of GII.10 to A-type saliva, B-type saliva, or pig gastric mucin (Koromyslova et al, 2017).

Short Description

This chimeric human antibody was made using a variable domain sequence of the original VHH format, for improved compatibility with existing reagents, assays and techniques.

AB01245-10.9 Datasheet

Price

£390.00

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