Anti-Norovirus P domain [Nano-27]
Catalogue Number: AB01245-23.9-ABA
| Manufacturer: | Vector Laboratories, Inc (ABA) |
| Type: | Recombinant Monoclonal |
| Shipping Condition: | Blue Ice |
| Unit(s): | 200 ug |
| Host name: | Rabbit |
| Clone: | Nano-27 |
| Isotype: | IgG |
| Immunogen: | An alpaca was injected with norovirus GII.10 virus-like particles (VLPs), and a phage display library constructed. Nano-27 was selected from this phage display library. |
| Application: | ELISA, NT, ITC, Crstapy |
Additional Text
Gene Name
ORF2
Purification
Purified
Gene ID
1491972
Uniprot ID
Q83884
Antibody Clonality
Recombinant Monoclonal
Storage Note
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Application Notes
The binding specificity of Nano-27 for the P domain of Norovirus strain GII.10 was confirmed using ELISA (Koromyslova et al, 2017). Using ITC the Kd of Nano-27 binding to the P domain of GII.10 was estimated as 9.50x10^-9 M (Koromyslova et al, 2017). The structure of Nano-27 in complex with G11.10 P domain was also obtained (Koromyslova et al, 2017). In neutralisation assays Nano-27 did not inhibit the binding of GII.10 to A-type saliva, B-type saliva, or pig gastric mucin (Koromyslova et al, 2017).
Short Description
This chimeric rabbit antibody was made using a variable domain sequence of the original VHH format, for improved compatibility with existing reagents, assays and techniques.
AB01245-23.9 Datasheet
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