Anti-Norovirus P domain [Nano-4]
Catalogue Number: AB01247-1.9-ABA
| Manufacturer: | Vector Laboratories, Inc (ABA) |
| Type: | Recombinant Monoclonal |
| Shipping Condition: | Blue Ice |
| Unit(s): | 200 ug |
| Host name: | Mouse |
| Clone: | Nano-4 |
| Isotype: | IgG1 |
| Immunogen: | An alpaca was injected with norovirus GII.10 virus-like particles (VLPs), and a phage display library constructed. Nano-4 was selected from this phage display library. |
| Application: | ELISA, NT, ITC, Crstapy |
Additional Text
Gene Name
ORF2
Purification
Purified
Gene ID
1491972
Uniprot ID
Q83884
Antibody Clonality
Recombinant Monoclonal
Storage Note
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Application Notes
The binding specificity of Nano-4 for the P domain of Norovirus strain GII.10 was confirmed using ELISA (Koromyslova et al, 2017). Nano-4 has stronger binding capabilities than Nano-27 or Nano-32; however, it also has limited cross-reactivity for other GI and GII norovirus strains. Nano-4 does not inhibit the binding of GII.10 to A-type saliva, B-type saliva, or pig gastric mucin as shown through neutralisation assays (Koromyslova et al, 2017). The crystal structure of Nano-4 in complex with the GII.17 P domain has been obtained (Koromyslova et al, 2017).
Short Description
This chimeric mouse antibody was made using a variable domain sequence of the original VHH format, for improved compatibility with existing reagents, assays and techniques.
AB01247-1.9 Datasheet
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