Anti-hINSR [IR 18-40]

Catalogue Number: AB01276-10.3-ABA

Manufacturer:Vector Laboratories, Inc (ABA)
Type:Recombinant Monoclonal
Alias:CD220; human insulin receptor; insulin receptor; HHF5; IR; 18 40
Shipping Condition:Blue Ice
Unit(s): 200 ug
Host name: Human
Clone: IR 18-40
Isotype: IgG1
Immunogen: This antibody was raised by immunising BALB/c mice with purified human placental insulin receptor.
Application: IP, IB

Additional Text

Gene Name

INSR

Uniprot ID

P06213

Gene ID

3643

Purification

Purified

Antibody Clonality

Recombinant Monoclonal

Storage Note

Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.

Application Notes

This antibody has been used in immunoprecipitation assays, with both radiolabelled human insulin receptor (hINSR) and hINSR-radiolabelled insulin complexes (Soos et al, 1986). This antibody has also been used in immunoblot analysis with purified hINSR (Soos et al, 1986), revealing that it reacts with the receptor's beta subunit. This antibody has been shown to have limited inhibitory effect on insulin binding to IM-9 cells (Soos et al, 1986).

Short Description

This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.