Anti-hINSR [IR 83-22]

Catalogue Number: AB01281-13.12-BT-ABA

Manufacturer:	Vector Laboratories, Inc (ABA)
Type:	Recombinant Monoclonal
Alias:	CD220; human insulin receptor; insulin receptor; HHF5; IR; 83 22
Shipping Condition:	Blue Ice
Unit(s):	1 mg
Host name:	Human
Clone:	IR 83-22
Isotype:	IgG4
Immunogen:	This antibody was raised by immunising BALB/c mice with IM-9 lymphocytes, and boosting with purified human placental insulin receptor prior to fusion.
Application:	IP, Inh, IB

Overview
Datasheets

Additional Text

Gene Name

INSR

Uniprot ID

P06213

Gene ID

3643

Purification

Purified

Antibody Clonality

Recombinant Monoclonal

Storage Note

Store at 4⁰C for up to 3 months. Note, this antibody is provided without added preservatives, it is therefore recommed this antibody be handled under sterile conditions. For longer storage, aliquot and store at -20⁰C.

Application Notes

This antibody has been used in immunoprecipitation assays, with both radiolabelled hINSR and hINSR-radiolabelled insulin complexes (Soos et al, 1986). It has also been used in immunoblot analysis with purified hINSR (Soos et al, 1986), revealing that it binds to the receptor's alpha subunit. This antibody has been shown to cause >80% inhibition of insulin binding to IM-9 cells (Soos et al, 1986), and behaves as a surrogate agonist.

Short Description

This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.

AB01281-13.12-BT Datasheet

Price

£1,655.00

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