Anti-IGF1R [IGFR 24-60]

Catalogue Number: AB01290-2.0-ABA

Manufacturer:	Vector Laboratories, Inc (ABA)
Type:	Monoclonal Secondary Antibody - Unconjugated
Alias:	IGF1 receptor; Insulin-like growth factor 1 receptor; type I IGF receptor; Insulin-like growth factor I receptor; IGF-I receptor; CD221; 24 60
Shipping Condition:	Blue Ice
Unit(s):	200 ug
Host name:	Mouse
Clone:	IGFR 24-60
Isotype:	IgG2a
Immunogen:	This antibody was raised by immunising BALB/c mice with transfected mouse fibroblasts expressing high levels of human IGF1R (IGF1R/3T3).
Application:	IP, Inh

Overview
Datasheets

Additional Text

Gene Name

IGF1R

Gene ID

3480

Uniprot ID

P08069

Purification

Purified

Antibody Clonality

Recombinant Monoclonal

Storage Note

Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.

Application Notes

The ability of this antibody to bind human IGF1R has been confirmed in IGF1 binding assays using both IG1FR-overexpressing IGF1R/3T3 cells and soluble receptors (Soos et al, 1992). This antibody efficiently precipitates human IGF1R solubilised from IGF1R/3T3 cells (Soos et al, 1992) and human placental membranes (Bailyes et al, 1997), and has been used in immunoprecipitation analysis of 293 cells transfected with IGF1R or chimeric IGF1R-insulin receptor (IR) constructs (Schumacher et al, 1993). When immobilised, this antibody has been shown to remove essentially all soluble, IGF1R/3T3-derived IGF1R (Soos et al, 1992) and human placental membrane-derived IGF1R (Soos et al, 1993) in immunodepletion experiments. This antibody strongly inhibits IGF1 binding to its receptor (Soos et al, 1992), and has been shown to suppress IGF1-mediated stimulation of skin fibroblast proliferation (Okubo et al 2003).

AB01290-2.0 Datasheet

Price

£390.00

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