Anti-CD96 [6A6]
Catalogue Number: AB01297-2.3-VXX-ABA
| Manufacturer: | Vector Laboratories, Inc (ABA) |
| Type: | Recombinant Monoclonal |
| Alias: | TACTILE; T-cell surface protein tactile; T cell-activated increased late expression protein |
| Shipping Condition: | Blue Ice |
| Unit(s): | 25 mg |
| Host name: | Mouse |
| Clone: | 6A6 |
| Isotype: | IgG2a |
| Immunogen: | This antibody was raised by immunising rats with murine CD96. |
| Application: | FC, Blk |
Additional Text
Gene Name
CD96
Uniprot ID
Q3U0X8
Gene ID
84544
Antibody Clonality
Recombinant Monoclonal
Storage Note
All VivopureX products are formulated in PBS only without addition of preservatives. To ensure optimal storage and prevent microbial contamination, only open and dispense under sterile conditions.
Application Notes
This antibody blocks murine CD96-CD155 interaction, and has been shown to bind to the first Ig domain of CD96 and compete with CD155 binding (Roman Aguilera et al, 2018). This antibody displays significant anti-metastatic activity in four experimental lung metastases models and one spontaneous tumour metastasis model (Roman Aguilera et al, 2018), with a potency greater than the anti-CD96 monoclonal antibodies 3.3 and 8B10. The binding specificity of this antibody has been determined in flow cytometric analysis of HEK-293 cells transfected with a range of CD96 Ig domain chimeric constructs (Roman Aguilera et al, 2018).
Short Description
This chimeric mouse antibody was made using the variable domain sequences of the original Rat IgG2a format, for improved compatibility with existing reagents, assays and techniques.
AB01297-2.3-VXX Datasheet
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